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Program

13:30

Registration

15:00

Welcome

Chair: Sara Oltra

  • Anna Bigas Salvans. Scientific Director of CIBERONC
  • Gema Moreno Bueno. Training and Mobility Programme Coordinator
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15:30

Plenary Session (CIBERONC)

Chair: Sara Oltra

  • Núria López Bigas. Computational analysis of cancer genomes.
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17:30

Round Table "Machine learning in precision medicine"

Chairs: María Camacho & Joaquín Olmedo

  • Núria López Bigas. Institute for Research in Biomedicine (IRB, Barcelona)
  • Victoria Suárez Ulloa. Plataforma de Bioinformática e Informática Sanitaria INIBIC-FPNS (A Coruña)
  • Joaquín Dopazo Blázquez. Clinical Bioinformatics Area, Fundación Pública Andaluza Progreso y Salud. Instituto de Biomedicina de Sevilla (IBIS, Sevilla).
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17:00h - Coffee break

17:30

Mechanisms of Tumor Progression Research Programme

Chair: Rubén Caloto & María Camacho

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Functional characterization of RHOA mutations in cancer: mutants with neomorphic properties in peripheral T-cell lymphomas.

Lucía Fernández Nevado. Centro de Investigación del Cáncer. Universidad de Salamanca. Xosé R. Bustelo group.

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An RNA processing transcriptional program under the control of β-catenin imposes chemotherapy resistance and poor prognosis in T-ALL patients.

Violeta García Hernández. Institut Hospital del Mar d'Investigacions Mèdiques. Anna Bigas group.

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Development of a bioprinted breast cancer model using tissue derived extracellular matrix.

Bárbara Blanco Fernández. Institute for Bioengineering of Catalonia. Elisabeth Engel group.

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18:15

Gastrointestinal Tumors Research Programme

Chair: Rubén Caloto

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Patient-derived organoids from primary tumors as models to study the differences between left- and right- sided colorectal cancer.

Blanca García Micó. INCLIVA Biomedical Research Institute. Universidad de Valencia. Andrés Cervantes group.

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The metabolic rewiring induced by impaired denitrosylation contributes to tumor progression and immune escape in colorectal cancer.

Rafael Mena Osuna. Maimónides Institute of Biomedical Research group of Córdoba. Enrique Aranda group.

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18:45

Closing Remarks

Chair: Rubén Caloto

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19:00

Poster party session

Poster programme at the end of the present document

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8:40

Welcome

Chair: Heribert Playà

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8:45

Hematological Tumors Research Programme

Chair: Heribert Playà

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The genomic and epigenomic footprints of Richter transformation in chronic lymphocytic leukemia.

Ferran Nadeu Prat. Institut d'Investigacions Biomèdiques August Pi i Sunyer. Elías Campo group.

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High frequency of small neoplastic B-cell clones in hospitalized COVID-19 patients: association with severity of infection.

Guillermo Oliva Ariza. Centro de Investigación del Cáncer. Universidad de Salamanca. José A. Orfao group.

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09:15

Plenary Lecture (CIBERBBN)

Chair: Juan Francisco Blández

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Mechanobiology of intestinal organoids and tumoroids.

Xavier Trepat Guixer.

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10:15

Breast Cancer Research Programme

Chair: Sara Oltra & Juan Francisco Blández

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Gasdermin B over-expression modulates HER2-targeted therapy resistance through LC3B/Rab7 interaction.

Manuel Gámez Chiachio.Instituto de Investigaciones Biomédicas "Alberto Sols". Universidad Autónoma de Madrid. Gema Moreno group.

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mTOR inhibition increases Trastuzumab-emtansine (T-DM1) activity in trastuzumab-resistant HER2-positive breast cancer.

Anna Hernández Prat. Institut Hospital del Mar d'Investigacions Mèdiques. Joan Albanell group.

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Targeted approaches for the effective treatment of triple negative breast cancer by combining senescence-inducing chemotherapy with senolytics.

Alba García Fernández. Instituto Interuniversitario de Reconocimiento Molecular y Desarrollo Tecnológico. Universidad Politécnica de Valencia. Ramón Martínez group.

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11:00h - Coffee break

11:30

Low Prevalence Tumors Research Programme

Chairs: Joaquín Olmedo & María Camacho

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Desmoplastic Small Round Cell Tumor on the spotlight.

Laura Lobo Selma. Instituto de Biomedicina de Sevilla. Universidad de Sevilla. Enrique de Álava group.

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Vitronectin-based polyethylene glycol hydrogels as mimicking tools for neuroblastoma.

Ezequiel Monferrer Garzarán. INCLIVA Biomedical Research Institute. Universidad de Valencia. Rosa Noguera group.

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BRAF V600E Mutation has a role in the LDL-mediated signalling pathways, increasing the aggressiveness in the thyroid tumor cells.

Giovanna Revilla Senra. Institut d'Investigacions Biomèdiques Sant Pau. Rosa Corcoy group.

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12:15

Round Table "Publishing in high impact journals"

Chairs: Cristina Megino & Mario Sánchez

  • Manuel Valiente Cortés. Centro Nacional de Investigaciones Oncológicas (CNIO, Madrid)
  • Direna Alonso Curbelo. Institute for Research in Biomedicine (IRB, Barcelona)
  • Javier Carmona Sanz. Team Manager in Springer Nature Group
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12:45

Respiratory Tract Tumors Research Programme

Chairs: Mario Sánchez & Juan Francisco Blández

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GAL3 as an immunosupresive regulator in lung cancer stemness. Prognostic and predictive implications in NSCLC.

Susana Torres Martínez. Fundación de Investigación Hospital General Universitario de Valencia. Carlos Camps group.

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Role of the interaction between the tumor suppressor SPINOPHILIN and the phosphatase PP1 in tumorigenesis.

Eva María Verdugo Sivianes. Instituto de Biomedicina de Sevilla. Universidad de Sevilla. Amancio Carnero group.

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Analysis of the predictive value of monitored routine clinical and molecular variables for stratifying immunotherapy-treated patients with Nonsmall Cell Lung Cancer.

Ana Delia Ramos Guerra. Universidad Politécnica de Madrid. Andrés Santos group.

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13:30

Round Table "Dissemination on social networks"

Chairs: Heribert Playà & Rubén Caloto

  • Lucía Almagro Ruz. Blogger "Diario de una científica"
  • Miriam Rivera Iglesias. Scientific illustrator at "Biomiics"
  • Noemí Gómez Gómez. Journalist at "Agencia EFE"
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14:00

Lunch

15:00

Social Event "The Challenge"

Chairs: Juan Francisco Blández & Mario Sánchez

Kahoot about the oral communications open to everyone coming in person to the event.

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15:45

Awards

Chairs: Heribert Playà & María Camacho

Prizes at the best predoctoral and postdoctoral communication and the best poster presentation.

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16:00

Closure

Chair: Heribert Playà

  • Núria Malats Riera. Training Programme Co-coordinator of CIBERONC
  • Rosa Villa Sanz. Training Programme Coordinator of CIBERBBN
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CIBER-BBN
BBN01: Delta-Radiomics signature for prediction of survival in advanced NSCLC patients treated with immunotherapy. Farina, B.
BBN02: Magnetic Resonance Imaging-based biomarker accurately identifies patients with nonalcoholic steatohepatitis and significant liver fibrosis: a multicenter, international, validation study. Martí-Aguado, D.
BBN03: Breast cancer protection after full-term pregnancy and r-hCG administration – Lessons from gene co-expression networks. Gómez-Pilar, J.
BBN04: Development and characterization of alginate microgels as 3D enviroments in Multiple Myeloma disease models. García-Briega, M.I.
BBN05: Proliferation and drug resistance of Multiple Myeloma cell lines cultured in a 3D biomimetic microgel. Clara-Trujillo, S.
BBN06: Label-free detection of micro-RNA-21 in plasma human samples for lung cancer diagnosis using an advanced nanophotonic biosensor. Calvo-Lozano, O.
BBN07: Navitoclax-based therapies improve cardiac function after doxorubicin-induced senescence in mice. Lérida-Viso, A.
BBN08: Parallel G-quadruplex Structures Increase Cellular Uptake and Cytotoxicity of 5-Fluoro- 2ʹ- deoxyuridine Oligomers in 5-Fluorouracil Resistant Cells. Clua, A.
BBN09: Multivalent Self-Assembled PEG-SN38 Nanosystems for Advanced Colorectal Cancer Therapy. Berardi, G.
BBN10: Targeting Glutathione with catalytic nanoparticles to promote cancer cell death. Aletá, J.
BBN11: Noble metal-based nanomaterials with multi-enzymatic mimicking response in tumor relevant conditions. García-Peiro, J.I.
Breast Cancer Research Programme
BC01: GSDMB protein isoforms are differently cleaved by proteases and promote distinct effects on pyroptotic cell death and mitochondrial damage. Sin, L.
BC02: Effect of therapy-induced senescence on the efficacy of ADCs. Duro-Sánchez, S.
BC03: Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Martínez-Sabadell, A.
BC04: p95HER2-CAR Ts as a safe immunotherapeutic strategy against HER2 positive breast tumours. Román-Alonso, M.
BC05: Antigen presentation machinery regulation shapes immunoediting of cancer stem cells during immune-checkpoint blockade resistance. Pérez-Núñez, I.
BC06: Neuregulin confers resistance to fulvestrant in breast cancer by activation of several signaling pathways. Almaráz-Postigo, S.
BC07: Mechanisms of resistance to T-DM1 and other anti-HER2 therapies and novel therapeutic strategies. Gandullo-Sánchez, L.
BC08: Understanding the role of Loxl3 in mouse melanomagenesis. Vázquez-Naharro, A.
BC09: Dual HER2 blockade and CDK4/6 inhibition modulate tumor-intrinsic immune response markers in HER2-positive breast cancer. Qin, M.
BC10: The key role of senescent cells in breast cancer progression. Lalinde, M.
BC11: The target antigen determines the mechanism of acquired resistance to T cell based therapies. Arenas, E.J.
BC12: Cellular localization and function of TGF-α in kidney cancer. Romero-Pérez, I.
BC13: Biomarking sensitivity to MEK5/ERK5. Matilla-Almazán, S.
Gatrointestinal Tumors Research Pogramme
GT01: Variant prioritization in liquid biopsy whole exome sequencing analysis to identify new actionable targets in patients with relapsing colon cancer. Martín-Arana, J.
GT02: Characterization of the tumor-infiltrating immune repertoire in Muscle Invasive Bladder Cancer. Benítez, R.
GT03: Patient-derived gastric tumor organoids: towards a precision medicine for gastric cancer patients. Cabeza-Segura, M.
GT04: Association between IgE, asthma and allergy, and pancreatic cancer risk. He, J.
GT05: GSK-3 inhibition as an immunotherapeutic approach in colorectal cancer. Mantrana, A.
GT06: Comparison of droplet digital PCR and amplicon-based sequencing in the detection of minimal residual disease in localized colon cancer. Tébar-Martínez, R.
GT07: A high-throughput screening identifies the combination of MK-1775 and Doxorubicin as a new therapeutic approach for MPNST. Creus-Bachiller, E.
GT08: Wnt pathway components in the predisposition to serrated polyposis. Quintana, I.
GT09: Targeting epigenetic modifications in colon cancer: CDX2 regulation as a mechanism to modulate cancer aggressiveness. Gimeno-Valiente, F. & Duréndez-Sáez, E.
GT10: Oral and fecal microbiome into the prediction of Pancreatic Cancer Risk. Jurado, F.
GT11: Variant and gene prioritization strategy to identify new hereditary colorectal cancer genes by NGS. Terradas, M.
GT12: Identifications of carcinogenesis and tumor progression processes in pancreatic adenocarcinoma using high-througput proteomics. Trilla-Fuertes, L.
Low Prevalence Tumors Research Programme
LPT01: New therapeutic approaches for Metformin in cancer. Ruiz-Mitjana, A.
LPT02: Identification of protein biomarkers in FFPE primary tissues to predict recurrence in endometrial cancer. Lopez-Gil, C.
LPT03: Non-Invasive Determination of Microsatellite Instability using liquid biopsies from patients with Endometrial Cancer. Casas-Arozamena, C.
LPT04: Genomic validation of endometrial cancer PDX models as a preclinical tool. Villafranca- Magdalena, B.
LPT05: Plasma circulating free DNA and circulating tumor cells as prognostic biomarkers for survival in patients with small cell lung cancer. Mondelo-Macía, P.
LPT06: Study of ARID1A context-dependent function in endometrial cancer. Megino-Luque ,C.
LPT07: Dissecting the role of Rloops in Ewing sarcoma chemosensitivity. Olmedo-Pelayo, J.
LPT08: Overcoming paradoxical kinase priming by a novel Type II MNK1 inhibitor. Cano, M.
Hematological Tumors Research Programme
TH01: A machine learning model based on tumor and immune biomarkers to predict undetectable MRD and survival in transplant-eligible multiple myeloma. Guerrero, C.
TH02: Minimally invasive profiling of tumor and immune cells to stratify risk in smoldering multiple myeloma (SMM): the iMMunocell study. Termini, R.
TH03: Landscape and clinical significance of long non-coding RNAs involved in multiple myeloma expressed fusion transcripts. Amundarain, A.
TH04: Validation of NKp80 as a universal marker for the identification of normal and tumor NK cells. Morán-Plata, F.J.
TH05: Systems biology approaches for the identification of metabolic vulnerabilities in Multiple Myeloma. Valcárcel, L.V.
TH06: Multi-omics characterization of Chronic Lymphocytic Leukemia.Landeira-Viñuela, A.
TH07: Testicular diffuse large B-cell lymphoma: clinico-biological characterization, treatment response and survival. López, C.
TH08: Generation of Patient-Derived Mantle Cell Lymphoma spheroids as a novel preclinical tool for immunotherapy testing. Araujo-Ayala, F.
TH09: Circulating tumor cells (CTC) are the most relevant diagnostic biomarker in transplanteligible multiple myeloma (MM). Garcés, J.J.
TH10: Integrated Multidimensional Flow Cytometry (MFC) and Next-Generation Sequencing (NGS) to Reconstruct Evolutionary Patterns from Dysplasia to Acute Myeloid Leukemia (AML). Simoes, C.
TH11: Synergistic effect of novel DAC inhibitors with chemotherapy drugs in Acute Myeloid Leukemia. Gimenez-Camino, N.
TH12: DDIT3, a potential dyserythropoiesis driver in myelodisplstic syndromes. Berastegui, N.
Mechanisms of Tumor Progression Research Programme
MTP01: RRAS2 activating mutants promote ovarian tumor formation. Clavaín, L.
MTP02: Characterization of the alternative splicing dynamics in T-Cell Acute Lymphoblastic Leukemia (T-ALL) and its clinical impact. Guillén, Y.
MTP03: VAV2 as a regulator of ribosome biogenesis in squamous lineages. Fernández-Parejo, N.
MTP04: IκBα is involved in pluripotency exit, mesodermal fate acquisition and in vitro hematopoiesis. Galán-Palma, L.
MTP05: Fetal conversion of p53 wildtype colorectal cancer cells imposes higher metastatic activity and poor prognosis. Solé, L.
MTP06: Uncovering the drivers of metastatic prostate cancer. Ercilla, A.
Respiratory Tract Tumors Research Programme
RTT01: Predictive value of immune parameters for the response to induction chemotherapy in head and neck squamous cell carcinoma. Sánchez-Canteli, M.
RTT02: Emerging role of Lectin-like transcript 1 (LLT1) expression as an independent poor prognostic factor in HPV-Negative Oropharyngeal Squamous Cell Carcinoma. Sánchez-Canteli, M.
RTT03: Study of soluble markers as predictive and prognostic biomarkers to immunotherapy with pembrolizumab in advanced non-small cell lung cancer. Torres-Martínez, S.
RTT04: The relevance of PAPPA, a new partner of the tumor suppressor SPN. Espinosa-Sánchez, A.
RTT05: Biomarkers profile related to stemness and therapy resistance in head and neck squamous cell carcinoma tumors. Sánchez-Díaz, L.
CIBER-BBN
O-BBN01: Detection of metabolic interactions in tumor cells by Surface-Enhanced Raman Scattering. Valera, P.S.
O-BBN02: Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Nonsinusoidal Alternating Magnetic Field Waveforms. ZEINOUN, M.
Breast Cancer Research Programme
O-BC01: Cancer associated fibroblast interaction with tumour cells in CTC clusters affects their metastatic capacity in a Zebrafish model. Hurtado-Blanco, P.
O-BC02: CTCs gene expression predicts CDKi response in luminal metastatic breast cancer patients. González-Conde, M.
Gatrointestinal Tumors Research Pogramme
O-GT01: Radiomics models for the prediction of overall survival in locally advanced head and neck squamous cell carcinoma. Bruixola, G.
O-GT02: Plasma whole exome sequencing for molecular characterization of advanced pancreatic tumors: beyond KRAS. Huerta, M.
O-GT03: SNAI1 expressing fibroblasts as predictive biomarkers for oxaliplatin. Galindo-Pumariño, C.
O-GT04: HLA Genetic Variability Shapes Pancreatic Cancer Risk and Prognosis. Langtry, A.
O-GT05: The Combination of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Liquid Biopsy Biomarkers Improves Prognosis Prediction in Metastatic Pancreatic Cancer. Toledano-Fonseca, M.
O-GT06: Temporal metabolomics patterns of breast cancer patients treated with neoadjuvant therapy. Zapater-Moros, A.
O-GT07: Differences between inherited and acquired polymerase proofreading deficiencies in cancer. Mur, P.
Low Prevalence Tumors Research Programme
O-LPT01: A therapeutically actionable pro-tumoral axis of cytokines involving interleukin-8, TNFα and IL-1β. Olivera, I.
Hematological Tumors Research Programme
O-TH01: No changes in the senescence and activation expression markers in blood circulating monocytes from systemic mastocytosis patients. Pérez-Pons, A.
O-TH02: Combined Treatment of Graft versus Host Disease using donor Regulatory T cells and ruxolitinib. Rodríguez-Gil, A.
Mechanisms of Tumor Progression Research Programme
O-MTP01: Disruption of SOS1 and SOS2 triggers alterations in adipose tissue. Olarte, A.
O-MTP02: Unravelling IQGAP1 and IQGAP2 Scaffold Proteins Role on Melanoma Invasive and Metastatic Capacities. García-Gómez, R.
O-MTP03: CD44v6 as a potential target for newly engineered antibody-based immunotherapy. Lodewijk, I.
O-MTP04: Development of aged skin/SCCs versus epidermal hyperplasia/BCCs in mice overexpressing IKKα in the nucleus or cytoplasm of keratinocytes, respectively. García-García, V.
Respiratory Tract Tumors Research Programme
O-RTT01: Next Generation Sequencing and liquid biopsy applicability in Non-Small Cell Lung Cancer patients. Moreno-Manuel, A.
O-RTT02: Prognostic relevance of Notch pathway activation in head and neck squamous cell carcinoma. Prieto-Fernández, L.
O-RTT03: Role of SOX2 in the development and progression of head and neck squamous cell carcinomas. Granda-Díaz, R.
O-RTT04: Role of MASTL Kinase in the response to radio- and chemotherapy in head and neck squamous cell carcinomas. Pozo-Agundo, E.
O-RTT05: LAG3 and HVEM combination as predictive biomarker to second-line immunotherapy treatment in advanced Non-Small Cell Lung Cancer (NSCLC) patients. Gallach-García, S.
O-RTT06:A living biobank of patient-derived organoids to model head and neck squamous cell carcinomas. Álvarez-González, M.
O-RTT07: A prognostic and predictive 6-gene-signature for non-metastatic non-small cell lung cancer. Peinado-Serrano, J.
O-RTT08:The different role of HIF1α and HIF2α in paragangliomas and pheochromocytomas. Celada, L.